Docking proteins

被引：35

作者：

Brummer, Tilman ^{[2
,3
,4
]}

Schmitz-Peiffer, Carsten ^{[5
]}

Daly, Roger J. ^{[1
]}

机构：

[1] Garvan Inst Med Res, Canc Res Program, Sydney, NSW 2010, Australia

[2] Univ Freiburg, Ctr Biol Syst Anal ZBSA, D-7800 Freiburg, Germany

[3] Univ Freiburg, Inst Biol 3, D-7800 Freiburg, Germany

[4] Univ Freiburg, Ctr Biol Signalling Studies, D-7800 Freiburg, Germany

[5] Garvan Inst Med Res, Diabet & Obes Program, Sydney, NSW 2010, Australia

来源：

FEBS JOURNAL | 2010年 / 277卷 / 21期

基金：

英国医学研究理事会;

关键词：

Dok; DOS; FRS2; Gab; IRS; protein modules; protein phosphorylation; SH2; signal transduction; tyrosine kinase; FIBROBLAST-GROWTH-FACTOR; INSULIN-RECEPTOR SUBSTRATE-1; PHOSPHOTYROSINE-BINDING DOMAIN; TYROSINE PHOSPHORYLATION SITES; SCAFFOLDING ADAPTER GAB2; SIGNAL-REGULATED KINASE; PLECKSTRIN-HOMOLOGY; PHOSPHATIDYLINOSITOL; 3-KINASE; EGF RECEPTOR; PTB DOMAIN;

D O I：

10.1111/j.1742-4658.2010.07865.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2-associated binder/Daughter of Sevenless, insulin receptor substrate, fibroblast growth factor receptor substrate 2 and downstream of tyrosine kinases protein families fall into this category. This minireview focuses on the structure, function and regulation of these proteins.

引用

页码：4356 / 4369

页数：14

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