Towards understanding the pathogenesis of rheumatic fever

被引:16
作者
Carapetis, JR
Currie, BJ
Good, MF
机构
[1] MENZIES SCH HLTH RES,DARWIN,NT,AUSTRALIA
[2] QUEENSLAND INST MED RES,BRISBANE,QLD 4006,AUSTRALIA
基金
英国医学研究理事会;
关键词
pathogenesis; rheumatic fever;
D O I
10.3109/03009749609080000
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute rheumatic fever results from an immunological response to group A streptococcal infection, but the exact nature of this response, and of the underlying host and organism characteristics, continues to evade researchers. Earlier models of rheumatic fever pathogenesis emphasised the importance of humoral immunity, but more recent work suggests that cellular immunity may play a primary role. Greater understanding of these disease mechanisms is allowing researchers to move towards the development of a vaccine for rheumatic fever.
引用
收藏
页码:127 / 131
页数:5
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