Convenient synthesis of 5,6,7,8-tetrahydroquinolin-8-ylamine and 6,7-dihydro-5H-quinolin-8-one

被引：8

作者：

McEachern, EJ ^{[1
]}

Yang, W ^{[1
]}

Chen, G ^{[1
]}

Skerlj, RT ^{[1
]}

Bridger, GJ ^{[1
]}

机构：

[1] AnorMed Inc, Dept Chem, Langley, BC V2Y 1N5, Canada

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 20期

关键词：

nitrosation; 5,6,7,8-tetrahydroquinoline; substituted pyridines; oxime reduction; oxime hydrolysis;

D O I：

10.1081/SCC-120024729

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A novel two-step synthesis of 5,6,7,8-tetrahydroquinolin-8-ylamine, involving regioselective nitrosation of 5,6,7,8-tetrahydroquinoline followed by oxime reduction, is described. Oxime hydrolysis affords 6,7-dihydro-5H-quinolin-8-one.

引用

页码：3497 / 3502

页数：6

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