How IRe1 reacts to ER stress

被引：197

作者：

Ron, David ^{[1
,2
]}

Hubbard, Stevan R. ^{[1
,3
]}

机构：

[1] NYU, Sch Med, Kimmel Ctr Biol, Med Skirball Inst, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Cell Biol, Dept Med, New York, NY 10016 USA

[3] NYU, Sch Med, Dept Pharmacol, New York, NY 10016 USA

来源：

CELL | 2008年 / 132卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.12.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The long-awaited structure of the effector portion of IRE1, the endoplasmic reticulum stress transducer, is published in this issue of Cell ( Lee et al., 2008). This structure provides new insight into the mysterious coupling of kinase and endoribonuclease activities in the oldest, most-conserved branch of the unfolded protein response in eukaryotes.

引用

页码：24 / 26

页数：4

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