Female rats show an increased sensibility to the forced swim test depressive-like stimulus in the hippocampus and frontal cortex 5-HT1A receptors

被引：13

作者：

Bellido, I ^{[1
]}

Gomez-Luque, A ^{[1
]}

Garcia-Carrera, P ^{[1
]}

Rius, F ^{[1
]}

de la Cuesta, FS ^{[1
]}

机构：

[1] Univ Malaga, Sch Med, Dept Clin Pharmacol & Therapeut, Malaga 29071, Spain

来源：

NEUROSCIENCE LETTERS | 2003年 / 350卷 / 03期

关键词：

gender; 5-HT1A; hippocampus; frontal cortex; forced swim test;

D O I：

10.1016/S0304-3940(03)00882-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Affective disorders are more common in women. The forced swim test acts like a depressive stimulus. Hippocampus and frontal cortex 5-HT1A receptors of female and male Wistar rats subjected to the forced swim test were compared with a sham group. The forced swim test diminishes (P < 0.05) the hippocampus H-3-80H-DPAT bound in the female rats (184 +/- 16 fmol/mg protein) with respect to the male rats (309 +/- 41 fmol/mg protein) and to the female sham rats (255 +/- 20 fmol/mg protein). The forced swim test increases the frontal cortex 5-HT1A receptors in the female rats with respect to the female sham group (40.4 +/- 5 versus 24.7 +/- 4 fmol/mg protein, P < 0.05). An increased sensibility of the 5-HT1A receptors to depressive-stimulus may be one mechanism underlying the higher prevalence of depression in female. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：145 / 148

页数：4

共 20 条

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