Effects of hormone replacement therapy on cancellous bone microstructure in postmenopausal women

被引:20
作者
Vedi, S
Croucher, PI
Garrahan, NJ
Compston, JE
机构
[1] UNIV CAMBRIDGE, ADDENBROOKES HOSP, SCH CLIN MED, DEPT MED, CAMBRIDGE CB2 2QQ, ENGLAND
[2] UNIV WALES COLL CARDIFF, COLL MED, DEPT PATHOL, CARDIFF, S GLAM, WALES
基金
英国惠康基金;
关键词
D O I
10.1016/8756-3282(96)00108-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Menopausal bone loss is associated crith disruption of cancellous bone architecture which has adverse mechanical effects and is believed to be irreversible, The aim of this study was to examine the effects of long-term hormone replacement therapy on cancellous bone structure in women with postmenopausal osteoporosis. Iliac crest biopsies from 22 women with osteopenia or osteoporosis were obtained before and after hormone replacement therapy (mean duration 23.5 months). Cancellous bone architecture was assessed by strut analysis, trabecular bone pattern factor, and marrow star volume. Post-treatment biopsies showed no significant changes in any of the structural indices assessed, Our results suggest that hormone replacement therapy preserves existing cancellous bone structure but provide no evidence that this treatment is able to reverse structural disruption in women with postmenopausal osteopenia or osteoporosis.
引用
收藏
页码:69 / 72
页数:4
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