The total synthesis of lipid I

被引:41
作者
VanNieuwenhze, MS [1 ]
Mauldin, SC [1 ]
Zia-Ebrahimi, M [1 ]
Aikins, JA [1 ]
Blaszczak, LC [1 ]
机构
[1] Eli Lilly & Co, Lilly Corp Ctr, Discovery Chem Res & Chem Proc Res & Dev, Lilly Res Labs, Indianapolis, IN 46285 USA
关键词
D O I
10.1021/ja016082o
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A total synthesis of lipid I (4), a membrane-associated intermediate in the bacterial cell wall (peptidoglycan) biosynthesis pathway, is reported. This highly convergent synthesis will enable further studies on bacterial resistance mechanisms and may provide insight toward the development of new chemotherapeutic agents with novel modes of action.
引用
收藏
页码:6983 / 6988
页数:6
相关论文
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