Enantioselective Bronsted acid catalyzed transfer hydrogenation: Organocatalytic reduction of imines

被引：429

作者：

Rueping, M ^{[1
]}

Sugiono, E ^{[1
]}

Azap, C ^{[1
]}

Theissmann, T ^{[1
]}

Bolte, M ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Chem & Chem Biol, D-60439 Frankfurt, Germany

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 17期

关键词：

D O I：

10.1021/ol0515964

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first enantioselective Bronsted acid catalyzed reduction of imines has been developed. This new organocatalytic transfer hydrogenation of ketimines with Hantzsch dihydropyridine as the hydrogen source offers a mild method to various chiral amines with high enantioselectivity. The stereochemistry of the chiral amines can be rationalized by a stereochemical model derived from an X-ray crystal structure of a chiral BINOL phosphate catalyst.

引用

页码：3781 / 3783

页数：3

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