Substituted 7H-pyrido[4,3-c]carbazoles with potent anti-HIV activity

被引：61

作者：

Hirata, K

Ito, C

Furukawa, H ^{[1
]}

Itoigawa, M

Cosentino, LM

Lee, KH

机构：

[1] Meijo Univ, Fac Pharm, Nagoya, Aichi 4688503, Japan

[2] Tokyo Gakugei Univ, Aichi 4700207, Japan

[3] Biotech Res Labs Inc, Rockville, MD 20850 USA

[4] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(98)00708-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several substituted 7H-pyrido[4,3-c]carbazoles were synthesized from the natural product mukonal and tested for inhibition of HIV replication in H9 lymphocytes. 5-Methoxy-7-methyl-7H-pyrido[4,3-c]carbazole (7) had an EC50 value of 0.0054 mu g/mL and the highest therapeutic index (TI = 503) in the series. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：119 / 122

页数：4

共 4 条

[1] SYNTHESIS OF 1-SUBSTITUTED ELLIPTICINES BY A NEW ROUTE TO PYRIDO[4,3-B]-CARBAZOLES [J].