Central administration of alloxan impairs glucose tolerance in rats

被引：3

作者：

Salkovic-Petrisic, M

Lackovic, Z

Hoyer, S

Riederer, P

机构：

[1] Univ Zagreb, Sch Med, Dept Pharmacol, HR-10000 Zagreb, Croatia

[2] Univ Zagreb, Croatian Inst Brain Res, HR-10000 Zagreb, Croatia

[3] Univ Heidelberg, Dept Pathol, D-6900 Heidelberg, Germany

[4] Univ Wurzburg, Clin Psychiat & Psychotherapy, Dept Clin Neurochem, D-97070 Wurzburg, Germany

[5] Univ Wurzburg, Clin Psychiat & Psychotherapy, NPF Ctr Excellence Labs, D-97070 Wurzburg, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2005年 / 112卷 / 10期

关键词：

alloxan; intracerebroventricular; glucose; insulin;

D O I：

10.1007/s00702-005-0360-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

By means of oral glucose tolerance test (OGTT), we investigated glucose tolerance in rats pre-treated with intracerebroventricular and subcutaneous non-diabetogenic dose of betacytotoxic drug alloxan 7 days before OGTT. Being normoglycemic and normoinsulinemic pre-OGTT, at 30 minutes post-OGTT, alloxan intracerebroventricularly-treated rats had a lower glucose and a higher insulin plasma levels in comparison with controls or alloxan subcutaneously treated animals. Centrally administered alloxan seems to have brain related effect on the regulation of peripheral glucose tolerance and insulin secretion.

引用

页码：1391 / 1395

页数：5

共 18 条

[1] INHIBITION OF DEPRIVATION-INDUCED FEEDING BY NALOXONE AND CHOLECYSTOKININ IN RATS - EFFECTS OF CENTRAL ALLOXAN [J].