Mutational analysis of ABC proteins

被引：72

作者：

Loo, Tip W. ^{[1
]}

Clarke, David M. ^{[1
,2
]}

机构：

[1] Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada

[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2008年 / 476卷 / 01期

基金：

加拿大健康研究院;

关键词：

ABC proteins; P-glycoprotein; CFTR; MRP1; BCRP; mutational analysis; ATPase activity; cysteine mutagenesis; disulfide cross-linking; arginine mutagenesis;

D O I：

10.1016/j.abb.2008.02.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 49 human members of the ATP-binding cassette (ABC) family of proteins are involved in a wide range of activities such as active transport of compounds across membranes, extraction of compounds out of membranes, functioning as ion channels, or regulators of channel activity. Mutations and/or overexpression of many of the proteins can have adverse effects on health. A goal in the study of ABC proteins is to understand their mechanisms of action. This review will focus on the mutational approaches that have been used to study the structure and mechanisms of some ABC proteins. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：51 / 64

页数：14

共 173 条

[1] The ABCs of immunology:: Structure and function of TAP, the transporter associated with antigen processing [J].