Activity-dependent accumulation of Ca2+ in axon and dendrites of them leech Leydig neuron

被引：4

作者：

Lohr, C ^{[1
]}

Beck, A ^{[1
]}

Deitmer, JW ^{[1
]}

机构：

[1] Univ Kaiserslautern, Abt Allgemeine Zool, D-67653 Kaiserslautern, Germany

来源：

NEUROREPORT | 2001年 / 12卷 / 17期

关键词：

action potential; confocal microscopy; Hirudo; voltage-activated calcium channel;

D O I：

10.1097/00001756-200112040-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have investigated Ca2+ changes evoked by single action potentials (APs) in axon and dendrites of leech Leydig neurons. Dendritic Ca2+ transients induced by an AP were twice as large as in the axon, and Ca2+ recovery was significantly faster in the dendrites as compared to the axon. The AP-induced, Ca2+ transients were blocked by Co2+ and suppressed in Ca2+-free saline, indicating Ca2+ influx through voltage-activated channels. During a train of APs, Ca2+ accumulated significantly more in the axon than in the dendrites. Suppression of the Ca2+ influx changed the shape of the action potential and increased the firing frequency. The results suggest a functional role of Ca2+ influx and Ca2+ accumulation during electrical activity in different neuronal subcompartments. NeuroReport 12:3649-3653 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：3649 / 3653

页数：5

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