Modeling within-host evolution of HIV: Mutation, competition and strain replacement

被引:44
作者
Ball, Colleen L.
Gilchrist, Michael A.
Coombs, Daniel
机构
[1] Univ British Columbia, Dept Math, Vancouver, BC V6T 1Z2, Canada
[2] Univ British Columbia, Inst Appl Math, Vancouver, BC V6T 1Z2, Canada
[3] Univ Tennessee, Dept Ecol & Evolut Biol, Knoxville, TN 37996 USA
基金
加拿大自然科学与工程研究理事会;
关键词
virus dynamics; selection-mutation models; HIV evolution; virus fitness;
D O I
10.1007/s11538-007-9223-z
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Virus evolution during infection of a single individual is a well-known feature of disease progression in chronic viral diseases. However, the simplest models of virus competition for host resources show the existence of a single dominant strain that grows most rapidly during the initial period of infection and competitively excludes all other virus strains. Here, we examine the dynamics of strain replacement in a simple model that includes a convex trade-off between rapid virus reproduction and long-term host cell survival. Strains are structured according to their within-cell replication rate. Over the course of infection, we find a progression in the dominant strain from fast- to moderately-replicating virus strains featuring distinct jumps in the replication rate of the dominant strain over time. We completely analyze the model and provide estimates for the replication rate of the initial dominant strain and its successors. Our model lays the groundwork for more detailed models of HIV selection and mutation. We outline future directions and application of related models to other biological situations.
引用
收藏
页码:2361 / 2385
页数:25
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