Plasma lipids and urinary albumin excretion rate in Type 1 diabetes mellitus: the EURODIAB IDDM Complications Study

被引:33
作者
Mattock, MB
Cronin, N
Cavallo-Perin, P
Idzior-Walus, B
Penno, G
Bandinelli, S
Standl, E
Kofinis, A
Fuller, JH
机构
[1] St Helier Hosp, SW Thames Inst Renal Res, Carshalton SM5 1AA, Surrey, England
[2] Cork Reg Hosp, Cork, Ireland
[3] Univ Turin, Dipartimento Med Interna, Turin, Italy
[4] Univ Sch Med, Dept Metab Dis, Krakow, Poland
[5] Cattedra Malattie Metab & Ricambio, Pisa, Italy
[6] Schwabinger Krankenhaus, Munich, Germany
[7] Hippokrateion Hosp, Ctr Diabet, Athens, Greece
[8] UCL, Dept Epidemiol & Publ Hlth, London, England
关键词
cholesterol; HDL-cholesterol; plasma lipids; triglycerides; Type 1 diabetes mellitus; urinary albumin excretion;
D O I
10.1046/j.1464-5491.2001.00411.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims To examine the relationship between increased urinary albumin excretion rate and fasting plasma lipids among male and female respondents to the EURODIAB IDDM Complications Study, and attempt to explain inconsistencies in previous reports. Methods A cross-sectional study of 3250 randomly selected Type 1 diabetic patients from 31 diabetes clinics in 16 European countries was carried out between 1989 and 1990. Plasma lipids and urinary albumin were measured centrally. The present analysis was confined to the subgroup of 2205 patients attending after a 10-12 h overnight fast. Mean age was 33 years (SD 10) and mean duration of Type 1 diabetes mellitus was 15 years (SD 9). Results The prevalence of microalbuminuria (24-h urinary albumin excretion rate 20-200 mug/min) was 21.7% (95% confidence interval 19.9-23.5) and macroalbuminuria (24-h urinary albumin excretion rate > 200 mug/min) 7.8% (6.6-9.0). In comparison to patients with normal urinary albumin excretion rate (< 20 <mu>g/min), and after controlling for age, sex, glycaemic control, duration of diabetes and current smoking, macroalbuminuria was associated with significantly (P < 0.01) increased fasting plasma triglycerides, cholesterol, LDL-cholesterol, cholesterol:HDL-cholesterol ratio and, in women, reduced HDL-cholesterol. In men and women with microalbuminuria, the only significant association was with increased plasma triglycerides. Conclusions These data confirm that there is an association between fasting plasma lipids and increasing urinary albumin excretion rate in European Type 1 diabetic patients. In microalbuminuric patients, however, the association was weaker than previously reported and partly explained by confounding factors.
引用
收藏
页码:59 / 67
页数:9
相关论文
共 43 条
[1]  
ANDERSEN AR, 1983, DIABETOLOGIA, V25, P496
[2]  
BARRETTCONNOR E, 1985, DHHS NIH PUBLICATION
[3]   LIPIDS, DIABETES, AND VASCULAR-DISEASE - THE TIME TO ACT [J].
BETTERIDGE, DJ .
DIABETIC MEDICINE, 1989, 6 (03) :195-218
[4]   PREDICTORS OF MICROALBUMINURIA IN INDIVIDUALS WITH IDDM [J].
COONROD, BA ;
ELLIS, D ;
BECKER, DJ ;
BUNKER, CH ;
KELSEY, SF ;
LLOYD, CE ;
DRASH, AL ;
KULLER, LH ;
ORCHARD, TJ .
DIABETES CARE, 1993, 16 (10) :1376-1383
[5]  
Deckert T, 1996, BRIT MED J, V312, P871
[6]   Renal involvement in type 1 (IDDM) diabetes in Spain [J].
Diamante, E .
DIABETES RESEARCH AND CLINICAL PRACTICE, 1997, 38 (02) :129-137
[7]  
DULLAART RPF, 1989, DIABETOLOGIA, V32, P685
[8]  
Fleiss J., 1986, Reliability of measurement: the design and analysis of clinical experiments
[9]  
FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
[10]   HEMOSTATIC VARIABLES ASSOCIATED WITH DIABETES AND ITS COMPLICATIONS [J].
FULLER, JH ;
KEEN, H ;
JARRETT, RJ ;
OMER, T ;
MEADE, TW ;
CHAKRABARTI, R ;
NORTH, WRS ;
STIRLING, Y .
BMJ-BRITISH MEDICAL JOURNAL, 1979, 2 (6196) :964-966