Macrophage scavenger receptors and host-derived ligands

被引：287

作者：

Pluddemann, Annette ^{[1
]}

Neyen, Claudine ^{[1
]}

Gordon, Siamon ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

METHODS | 2007年 / 43卷 / 03期

基金：

英国医学研究理事会;

关键词：

scavenger receptors; endogenous ligand; molecular chaperones; antigen presentation; atherosclerosis; Alzheimer's disease;

D O I：

10.1016/j.ymeth.2007.06.004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The scavenger receptors are a large family of molecules that are structurally diverse and have been implicated in a range of functions. They are expressed by myeloid cells, selected endothelial cells and some epithelial cells and recognise many different ligands, including microbial pathogens as well as endogenous and modified host-derived molecules. This review will focus on the eight classes of scavenger receptors (class A-H) in terms of their structure, expression and recognition of host-derived ligands. Scavenger receptors have been implicated in a range of physiological and pathological processes, such as atherosclerosis and Alzheimer's disease, and function in adhesion and tissue maintenance. More recently, some of the scavenger receptors have been shown to mediate binding and endocytosis of chaperone proteins, such as the heat shock proteins, thereby playing an important role in antigen cross-presentation. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：207 / 217

页数：11

共 145 条

[1]

ABUMRAD NA, 1993, J BIOL CHEM, V268, P17665

[2]

Identification of scavenger receptor SR-BI as a high density lipoprotein receptor [J].