Clips and clasps and cellular dynamics

被引：157

作者：

Galjart, N ^{[1
]}

机构：

[1] Erasmus MC, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 06期

关键词：

D O I：

10.1038/nrm1664

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The dynamic properties of microtubules are regulated by plus-end tracking proteins (+TIPs), which associate with the distal ends of microtubules. Among the +TIPs are cytoplasmic linker proteins ( CLIPs), which promote microtubule growth and regulate dynein dynactin localization, and CLIP-associating proteins (CLASPs), which stabilize specific subsets of microtubules on reception of signalling cues. CLIPs and CLASPs interact and cooperate to direct the microtubule network, thereby regulating cellular asymmetry.

引用

页码：487 / 498

页数：12

共 109 条

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