New molecularly targeted therapies for lung cancer

被引：176

作者：

Sun, Sophie

Schiller, Joan H.

Spinola, Monica

Minna, John D.

机构：

[1] Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Div Hematol & Oncol, Dallas, TX 75390 USA

[3] Univ Texas, SW Med Ctr, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 10期

关键词：

D O I：

10.1172/JCI31809

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lung cancer is the leading cause of cancer death worldwide. The disease is particularly difficult to detect, and patients often present at an advanced stage. Current treatments have limited effectiveness, and unfortunately, the prognosis remains poor. Recent insights into the molecular pathogenesis and biologic behavior of lung cancer have led to the development of rationally designed methods of early detection, prevention, and treatment of this disease. This article will review the important clinical implications of these advances, with a focus on new molecularly targeted therapies currently in development.

引用

页码：2740 / 2750

页数：11

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