Nanopore/electrode structures for single-molecule biosensing

被引：33

作者：

Ayub, Mariam ^{[1
,2
]}

Ivanov, Aleksandar ^{[1
,2
]}

Instuli, Emanuele ^{[1
,2
]}

Cecchini, Michael ^{[1
,2
]}

Chansin, Guillaume ^{[1
,2
]}

McGilvery, Catriona ^{[3
]}

Hong, Jongin ^{[1
,2
]}

Baldwin, Geoff ^{[4
]}

McComb, David ^{[3
]}

Edel, Joshua B. ^{[1
,2
]}

Albrecht, Tim ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Inst Biomed Engn, London SW7 2AZ, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2AZ, England

[4] Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England

来源：

ELECTROCHIMICA ACTA | 2010年 / 55卷 / 27期

关键词：

Nanopore sensing; Solid state; DNA sequencing; Electrochemical nanoscience; Ion transport; ION-TRANSPORT; NANOPORE MEMBRANES; DNA; NOISE; PORES; TRANSLOCATION; RECTIFICATION; FABRICATION; RECORDINGS; MECHANISM;

D O I：

10.1016/j.electacta.2010.03.051

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

Biological and solid-state nanopores have recently attracted much interest as ultrafast DNA fragment sizing and sequencing devices Their potential however goes far beyond DNA sequencing In particular nanopores offer perspectives of single-molecule (bio)sensing at physiologically relevant concentrations which is key for studying protein/protein or protein/DNA interactions Integration of electrode structures into solid-state nanopore devices moreover enables control and fast switching of the pore properties e g for active control of biopolymer transport through the nanopore We present some of recent work in this area namely the fabrication and characterization of nanopore/electrode architectures for single-(bio)molecule sensing Specifically we introduce a new technique to fabricate ultra-small metal nanopores with diameters smaller than 20 nm based on ion current feedback (ICF) controlled electrodeposition It offers precise control of the pore conductance is easily multiplexed and can be extended to a wide range of different metals (C) 2010 Elsevier Ltd All rights reserved

引用

页码：8237 / 8243

页数：7

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