Gene therapy of hepatocarcinoma:: a long way from the concept to the therapeutical impact

被引：21

作者：

Gérolami, R

Uch, R

Bréchot, C

Mannoni, P

Bagnis, C

机构：

[1] EFS Alpes Mediterranee, Dept Therapie Cellulaire & Genique, F-13392 Marseille CDX5, France

[2] Hop La Conception, Serv Hepatol, Marseille, France

[3] Fac Necker, INSERM, U370, Paris, France

来源：

CANCER GENE THERAPY | 2003年 / 10卷 / 09期

关键词：

hepatocarcinoma; review; gene transfer;

D O I：

10.1038/sj.cgt.7700610

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hepatocellular carcinoma (HCC), the most prevalent histological form of primary liver cancer is one of the most frequent cancer worldwide. This pathology still requires the development of new therapeutical approaches. Gene therapy strategies focusing on the genetic manipulation of accessory cells involved in the immune reaction against cancer cells, or on the direct transduction of tumor cells with transgenes able to "suicide'' cancer cells have been largely developed for more than ten years.

引用

页码：649 / 660

页数：12

共 160 条

[1]

Aghi M, 2000, J GENE MED, V2, P148, DOI 10.1002/(SICI)1521-2254(200005/06)2:3<148::AID-JGM105>3.0.CO

[2]

2-Q

[3] Update on hepatic stem cells [J].