Immune-mediated mechanisms influencing the efficacy of anticancer therapies

被引：146

作者：

Coffelt, Seth B. ^{[1
]}

de Visser, Karin E. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Immunol, NL-1066 CX Amsterdam, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2015年 / 36卷 / 04期

基金：

欧洲研究理事会;

关键词：

cancer; inflammation; adaptive immune cells; anticancer therapy; mouse model; TUMOR-ASSOCIATED MACROPHAGES; REGULATORY T-CELLS; ENDOTHELIAL GROWTH-FACTOR; INFILTRATING MYELOID CELLS; HUMAN MONOCLONAL-ANTIBODY; METASTATIC BREAST-CANCER; ENGINEERED MOUSE MODELS; CHEMOKINE LIGAND 2; CARLUMAB CNTO 888; SUPPRESSOR-CELLS;

D O I：

10.1016/j.it.2015.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not only determined by their direct effects on cancer cells but also by off-target effects within the host immune system. Cytotoxic treatment regimens elicit several changes in immune-related parameters including the composition, phenotype, and function of immune cells. Here we discuss the impact of innate and adaptive immune cells on the success of anticancer therapy. In this context we examine the opportunities to exploit host immune responses to boost tumor clearing, and highlight the challenges facing the treatment of advanced metastatic disease.

引用

页码：198 / 216

页数：19

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