Ability of pneumococcal serotypes and clones to cause acute otitis media:: Implications for the prevention of otitis media by conjugate vaccines

被引:61
作者
Hanage, WP
Auranen, K
Syrjänen, R
Herva, E
Mäkelä, PH
Kilpi, T
Spratt, BG
机构
[1] Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Dept Infect Dis Epidemiol, Fac Med, London W2 1PG, England
[2] Natl Publ Hlth Inst, Dept Vaccines, Helsinki 00100, Finland
[3] Natl Publ Hlth Inst, Dept Microbiol, Oulu 90101, Finland
关键词
D O I
10.1128/IAI.72.1.76-81.2004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The relative abilities of pneumococcal serotypes and strains (clones) to cause acute otitis media (AOM) were investigated by comparing the serotypes and genotypes of pneumococci recovered from cases of AOM (n = 149) in children <2 years of age with those from nasopharyngeal carriage (n = 288) in age-matched controls from the same region. The odds ratio (OR) for association of pooled vaccine serotypes with AOM was found to be slightly elevated over unity, although this was not significantly different from that of pooled nonvaccine or vaccine-related serotypes. Comparing individual serotypes, 19F and 23F had 2- to 2.5-fold higher ORs, although these were not markedly different from the ORs of nonvaccine serotypes. None of the major clones had an OR that was significantly greater than the average, and the differences in ORs among serotypes and clones were much less than those for invasive disease, suggesting little variation in their ability to cause AOM. We conclude that serotype replacement may reduce the long-term efficacy of these vaccines against AOM.
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页码:76 / 81
页数:6
相关论文
共 19 条
[1]   Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children [J].
Black, S ;
Shinefield, H ;
Fireman, B ;
Lewis, E ;
Ray, P ;
Hansen, JR ;
Elvin, L ;
Ensor, KM ;
Hackell, J ;
Siber, G ;
Malinoski, F ;
Madore, D ;
Chang, I ;
Kohberger, R ;
Watson, W ;
Austrian, R ;
Edwards, K .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (03) :187-195
[2]   Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumonia [J].
Black, SB ;
Shinefield, HR ;
Ling, S ;
Hansen, J ;
Fireman, B ;
Spring, D ;
Noyes, J ;
Lewis, E ;
Ray, P ;
Lee, J ;
Hackell, J .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2002, 21 (09) :810-815
[4]   Direct expenditures related to otitis media diagnoses: Extrapolations from a pediatric medicaid cohort [J].
Bondy, J ;
Berman, S ;
Glazner, J ;
Lezotte, D .
PEDIATRICS, 2000, 105 (06) :art. no.-e72
[5]   Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential [J].
Brueggemann, AB ;
Griffiths, DT ;
Meats, E ;
Peto, T ;
Crook, DW ;
Spratt, BG .
JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (09) :1424-1432
[6]   A multilocus sequence typing scheme for Streptococcus pneumoniae:: identification of clones associated with serious invasive disease [J].
Enright, MC ;
Spratt, BG .
MICROBIOLOGY-UK, 1998, 144 :3049-3060
[7]   Efficacy of a pneumococcal conjugate vaccine against acute otitis media [J].
Eskola, J ;
Kilpi, T ;
Palmu, A ;
Jokinen, J ;
Haapakoski, J ;
Herva, E ;
Takala, A ;
Käyhty, H ;
Karma, P ;
Kohberger, R ;
Siber, G ;
Mäkela, PH ;
Lockhart, S ;
Ecrola, M .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (06) :403-409
[8]   EPIDEMIOLOGIC STUDIES OF STREPTOCOCCUS-PNEUMONIAE IN INFANTS - ACQUISITION, CARRIAGE, AND INFECTION DURING THE 1ST 24 MONTHS OF LIFE [J].
GRAY, BM ;
CONVERSE, GM ;
DILLON, HC .
JOURNAL OF INFECTIOUS DISEASES, 1980, 142 (06) :923-933
[9]   Determining confidence intervals when measuring genetic diversity and the discriminatory abilities of typing methods for microorganisms [J].
Grundmann, H ;
Hori, S ;
Tanner, G .
JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (11) :4190-4192
[10]   Which pneumococcal serogroups cause the most invasive disease: Implications for conjugate vaccine formulation and use, part I [J].
Hausdorff, WP ;
Bryant, J ;
Paradiso, PR ;
Siber, GR .
CLINICAL INFECTIOUS DISEASES, 2000, 30 (01) :100-121