Natural killer T cells: natural or unnatural regulators of autoimmunity?

被引：103

作者：

Hammond, KJL ^{[1
]}

Kronenberg, M ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.coi.2003.09.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer T (NKT) cells are a unique lymphocyte subtype implicated in the regulation of autoimmunity, particularly diabetes and experimental allergic encephalomyelitis in animal models. In some reports, NKT-cell regulation was revealed only following vigorous activation by a synthetic glycolipid, a process that might not occur naturally. Patients with diverse autoimmune diseases have reduced NKT-cell counts and, in diabetes and multiple sclerosis, effective NKT-cell regulation correlates with the secretion of Th2 cytokines. Although current controversy surrounds the importance of NKT cells and their modes of action, they represent a potentially important clinical target.

引用

页码：683 / 689

页数：7

共 72 条

[1] Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity [J].

Akbari, O ;

Stock, P ;

Meyer, E ;

Kronenberg, M ;

Sidobre, S ;

Nakayama, T ;

Taniguchi, M ;

Grusby, MJ ;

DeKruyff, RH ;

Umetsu, DT .

NATURE MEDICINE, 2003, 9 (05) :582-588

[2] Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission [J].

Araki, M ;

Kondo, T ;

Gumperz, JE ;

Brenner, MB ;

Miyake, S ;

Yamamura, T .

INTERNATIONAL IMMUNOLOGY, 2003, 15 (02) :279-288

[3] Association between alpha beta TCR(+)CD4(-)CD8(-) T-cell deficiency and IDDM in NOD/Lt mice [J].

Baxter, AG ;

Kinder, SJ ;

Hammond, KJL ;

Scollay, R ;

Godfrey, DI .

DIABETES, 1997, 46 (04) :572-582

[4] NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic β cells [J].

Beaudoin, L ;

Laloux, V ;

Novak, J ;

Lucas, B ;

Lehuen, A .

IMMUNITY, 2002, 17 (06) :725-736

[5]

Burdin N, 1999, EUR J IMMUNOL, V29, P2014, DOI 10.1002/(SICI)1521-4141(199906)29:06<2014::AID-IMMU2014>3.0.CO

[6]

2-G

[7] Deficiency in β2-microglobulin, but not CD1, accelerates spontaneous lupus skin disease while inhibiting nephritis in MRL-Faslpr mice:: An example of disease regulation at the organ level [J].

Chan, OTM ;

Paliwal, V ;

McNiff, JM ;

Park, SH ;

Bendelac, A ;

Shlomchik, MJ .

JOURNAL OF IMMUNOLOGY, 2001, 167 (05) :2985-2990

[8] A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas [J].

Crowe, NY ;

Smyth, MJ ;

Godfrey, DI .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (01) :119-127

[9] Prolonged IFN-γ-producing NKT response induced with α-galactosylceramide-loaded DCs [J].

Fujii, S ;

Shimizu, K ;

Kronenberg, M ;

Steinman, RM .

NATURE IMMUNOLOGY, 2002, 3 (09) :867-+

[10] Activation of invariant NKT cells by αGalCer administration protects mice from MOG35-55-induced EAE:: critical roles for administration route and IFN-γ [J].

Furlan, R ;

Bergami, A ;

Cantarella, D ;

Brambilla, E ;

Taniguchi, M ;

Dellabona, P ;

Casorati, G ;

Martino, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (07) :1830-1838

← 1 2 3 4 5 6 7 8 →