Structural biology - Prying into prions

被引：56

作者：

Dobson, CM ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

NATURE | 2005年 / 435卷 / 7043期

关键词：

D O I：

10.1038/435747a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Various aberrant protein forms are the subject of intense research. It is not easy to probe their structures, but studies that have done so provide telling information about their biological properties.

引用

页码：747 / 749

页数：3

共 12 条

[1] Transmissible spongiform encephalopathies, amyloidoses and yeast prions: Common threads? [J].

Caughey, B .

NATURE MEDICINE, 2000, 6 (07) :751-754

[2] Protein folding and misfolding [J].

Dobson, CM .

NATURE, 2003, 426 (6968) :884-890

[3] The protofilament structure of insulin amyloid fibrils [J].

Jimenez, JL ;

Nettleton, EJ ;

Bouchard, M ;

Robinson, CV ;

Dobson, CM ;

Saibil, HR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (14) :9196-9201

[4] Structural insights into a yeast prion illuminate nucleation and strain diversity [J].

Krishnan, R ;

Lindquist, SL .

NATURE, 2005, 435 (7043) :765-772

[5] Structure of the cross-β spine of amyloid-like fibrils [J].

Nelson, R ;

Sawaya, MR ;

Balbirnie, M ;

Madsen, AO ;

Riekel, C ;

Grothe, R ;

Eisenberg, D .

NATURE, 2005, 435 (7043) :773-778

[6] Self-propagating, molecular-level polymorphism in Alzheimer's β-amyloid fibrils [J].

Petkova, AT ;

Leapman, RD ;

Guo, ZH ;

Yau, WM ;

Mattson, MP ;

Tycko, R .

SCIENCE, 2005, 307 (5707) :262-265

[7] Prion diseases and the BSE crisis [J].

Prusiner, SB .

SCIENCE, 1997, 278 (5336) :245-251

[8] Correlation of structural elements and infectivity of the HET-s prion [J].

Ritter, C ;

Maddelein, ML ;

Siemer, AB ;

Lührs, T ;

Ernst, M ;

Meier, BH ;

Saupe, SJ ;

Riek, R .

NATURE, 2005, 435 (7043) :844-848

[9] Folding proteins in fatal ways [J].

Selkoe, DJ .

NATURE, 2003, 426 (6968) :900-904

[10]

Sunde M, 1997, ADV PROTEIN CHEM, V50, P123, DOI 10.1016/S0065-3233(08)60320-4

← 1 2 →