ChIPping away at gene regulation

被引：41

作者：

Massie, Charles E. ^{[1
]}

Mills, Ian G. ^{[1
]}

机构：

[1] CRUK Cambridge Res Inst, Uro Oncol Res Grp, Li Ka Shing Ctr, Cambridge CB2 ORE, England

来源：

EMBO REPORTS | 2008年 / 9卷 / 04期

基金：

英国医学研究理事会;

关键词：

chromatin immunoprecipitation; gene expression; transcription factor;

D O I：

10.1038/embor.2008.44

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The coordinated regulation of gene expression in higher eukaryotes is complex and poorly understood. Recent technological advances have allowed the first insights into these networks on a genome-wide scale. These investigations have identified transcription factor target sites in the genome and successfully predicted cooperative interactions with other factors. However, a detailed understanding of the processes that coordinate gene expression remains elusive. Here, we highlight the advances that have been made using current methods, and the need for new technologies to address the gaps in our knowledge and to map these complex pathways further.

引用

页码：337 / 343

页数：7

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