New insights into atopic dermatitis

被引：1149

作者：

Leung, DYM ^{[1
]}

Boguniewicz, M

Howell, MD

Nomura, I

Hamid, OA

机构：

[1] Univ Colorado, Ctr Hlth Sci, Div Pediat Allergy Immunol, Natl Jewish Med & Res Ctr,Dept Pediat, Denver, CO 80202 USA

[2] Meakins Christie Labs, Montreal, PQ, Canada

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 05期

关键词：

D O I：

10.1172/JCI200421060

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Atopic dermatitis is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers and is often the first step in the atopic march that results in asthma and allergic rhinitis. The clinical phenotype that characterizes atopic dermatitis is the product of interactions between susceptibility genes, the environment, defective skin barrier function, and immunologic responses. This review summarizes recent progress in our understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies.

引用

页码：651 / 657

页数：7

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