The prolyl isomerase Pin1 in breast development and cancer

被引：65

作者：

Wulf, G ^{[1
]}

Ryo, A ^{[1
]}

Liou, YC ^{[1
]}

Lu, KP ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med,Dept Med, Canc Biol Program,Div Hematol Oncol, Boston, MA 02215 USA

来源：

BREAST CANCER RESEARCH | 2003年 / 5卷 / 02期

关键词：

breast cancer; breast development; cyclin D1; Pin1; phosphorylation signaling;

D O I：

10.1186/bcr572

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer. Its overexpression can lead to upregulation of cyclin D1 and transformation of breast epithelial cells in collaboration with the oncogenic pathways. In contrast, inhibition of Pin1 can suppress the transformation of breast epithelial cells. In addition, Pin1 knockout in mice prevents massive proliferation of breast epithelial cells during pregnancy. Pin1 plays a pivotal role in breast development and may be a promising new anticancer target.

引用

收藏

页码：76 / 82

页数：7

相关论文

共 96 条

[41] Current status of clinical trials of farnesyltransferase inhibitors [J].

Karp, JE ;

Kaufmann, SH ;

Adjei, AA ;

Lancet, JE ;

Wright, JJ ;

End, DW .

CURRENT OPINION IN ONCOLOGY, 2001, 13 (06) :470-476

[42] Pin1 modulates the dephosphorylation of the RNA polymerase IIC-terminal domain by yeast Fcp1 [J].

Kops, O ;

Zhou, XZ ;

Lu, KP .

FEBS LETTERS, 2002, 513 (2-3) :305-311

[43] Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway [J].

Lee, RJ ;

Albanese, C ;

Fu, MF ;

D'Amico, M ;

Lin, B ;

Watanabe, G ;

Haines, GK ;

Siegel, PM ;

Hung, MC ;

Yarden, Y ;

Horowitz, JM ;

Muller, WJ ;

Pestell, RG .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (02) :672-683

[44] β-catenin, a novel prognostic marker for breast cancer:: Its roles in cyclin D1 expression and cancer progression [J].

Lin, SY ;

Xia, WY ;

Wang, JC ;

Kwong, KY ;

Spohn, B ;

Wen, Y ;

Pestell, RG ;

Hung, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4262-4266

[45] Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes [J].

Liou, YC ;

Ryo, A ;

Huang, HK ;

Lu, PJ ;

Bronson, R ;

Fujimori, F ;

Uchida, T ;

Hunter, T ;

Lu, KP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1335-1340

[46] Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1 [J].

Liu, WF ;

Youn, HD ;

Zhou, XZ ;

Lu, KP ;

Liu, JO .

FEBS LETTERS, 2001, 496 (2-3) :105-108

[47]

Lu KP, 1996, NATURE, V380, P544

[48] Pinning down proline-directed phosphorylation signaling [J].

Lu, KP ;

Liou, YC ;

Zhou, XZ .

TRENDS IN CELL BIOLOGY, 2002, 12 (04) :164-172

[49]

LU KP, 2002, IN PRESS BIOESSAYS

[50]

Lu PJ, 1999, NATURE, V399, P784

← 1 2 3 4 5 6 7 8 9 10 →