NF-κB, Inflammation, and Metabolic Disease

被引：2327

作者：

Baker, Rebecca G. ^{[1
]}

Hayden, Matthew S. ^{[1
]}

Ghosh, Sankar ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Microbiol & Immunol, New York, NY 10032 USA

来源：

CELL METABOLISM | 2011年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

INDUCED INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; TYPE-2; DIABETES-MELLITUS; PANCREATIC BETA-CELLS; REGULATORY T-CELLS; KINASE IKK-EPSILON; HIGH-FAT DIET; ADIPOSE-TISSUE;

D O I：

10.1016/j.cmet.2010.12.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-kappa B in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.

引用

页码：11 / 22

页数：12

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