Molecular genetic detection of female carriers of protan defects

被引：17

作者：

Kainz, PM

Neitz, M

Neitz, J

机构：

[1] Med Coll Wisconsin, Dept Cellular Biol & Anat, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Ophthalmol, Milwaukee, WI 53226 USA

来源：

VISION RESEARCH | 1998年 / 38卷 / 21期

关键词：

method; photopigment genes; heterozygous carrier; colour vision defects;

D O I：

10.1016/S0042-6989(97)00366-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Females heterozygous for congenital colour vision defects are of interest because they are believed to have cone photoreceptor ratios and cone photopigments that differ from normal. We describe a molecular genetic method to identify protan carriers that involves characterizing the genes that occur in the most upstream position in each of the X-chromosome photopigment gene arrays. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：3365 / 3369

页数：5

相关论文

共 10 条

[1] A STUDY OF WOMEN HETEROZYGOUS FOR COLOR DEFICIENCIES [J].

JORDAN, G ;

MOLLON, JD .

VISION RESEARCH, 1993, 33 (11) :1495-1508

[2] Color vision in two observers with highly biased LWS/MWS cone ratios [J].

Miyahara, E ;

Pokorny, J ;

Smith, VC ;

Baron, R ;

Baron, E .

VISION RESEARCH, 1998, 38 (04) :601-612

[3] 4 CONE PIGMENTS IN WOMEN HETEROZYGOUS FOR COLOR DEFICIENCY [J].

NAGY, AL ;

MACLEOD, DIA ;

HEYNEMAN, NE ;

EISNER, A .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA, 1981, 71 (06) :719-722

[4] MOLECULAR-GENETICS OF INHERITED VARIATION IN HUMAN COLOR-VISION [J].

NATHANS, J ;

PIANTANIDA, TP ;

EDDY, RL ;

SHOWS, TB ;

HOGNESS, DS .

SCIENCE, 1986, 232 (4747) :203-210

[5] MOLECULAR-GENETICS OF HUMAN COLOR-VISION - THE GENES ENCODING BLUE, GREEN, AND RED PIGMENTS [J].

NATHANS, J ;

THOMAS, D ;

HOGNESS, DS .

SCIENCE, 1986, 232 (4747) :193-202

[6] Visual pigment gene structure and the severity of color vision defects [J].

Neitz, J ;

Neitz, M ;

Kainz, PM .

SCIENCE, 1996, 274 (5288) :801-804

[7] NUMBERS AND RATIOS OF VISUAL PIGMENT GENES FOR NORMAL RED-GREEN COLOR-VISION [J].

NEITZ, M ;

NEITZ, J .

SCIENCE, 1995, 267 (5200) :1013-1016

[8]

PRINCE AM, 1992, BIOTECHNIQUES, V12, P358

[9]

SCHMIDT I, 1955, Am J Optom Arch Am Acad Optom, V32, P404

[10] Relating color discrimination to photopigment genes in deutan observers [J].

Shevell, SK ;

He, JC ;

Kainz, P ;

Neitz, J ;

Neitz, M .

VISION RESEARCH, 1998, 38 (21) :3371-3376