Ginkgo biloba leave extract:: Biological, medicinal, and toxicological effects

被引：238

作者：

Chan, Po-Chuen ^{[1
]}

Xia, Qingsu ^{[2
]}

Fu, Peter P. ^{[2
]}

机构：

[1] NIEHS, Res Triangle Pk, NC 27709 USA

[2] Natl Ctr Toxicol Res, Jefferson, AR 72079 USA

来源：

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS | 2007年 / 25卷 / 03期

关键词：

Gingko biloba leave extract; biological and toxicological effects; ginkgolidc; quercetin;

D O I：

10.1080/10590500701569414

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ginkgo biloba leave extract is among the most widely sold herbal dietary supplements in the United States. Its purported biological effects include: scavenging free radical; lowering oxidative stress; reducing neural damages, reducing platelets aggregation; anti-inflammation; anti-tumor activities; and anti-aging. Clinically, it has been prescribed to treat CNS disorders such as Alzheimer's disease and cognitive deficits. It exerts allergy and changes in bleeding time. While its mutagenicity or carcinogenic activity has not been reported, its components, quercetin, kaempferol and rutin have been shown to be genotoxic. There are no standards or guidelines regulating the constituent components of Ginkgo biloba leave extract nor are exposure limits imposed. Safety evaluation of Ginkgo biloba leave extract is being conducted by the U.S. National Toxicology Program.

引用

页码：211 / 244

页数：34

共 161 条

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