Relationship between C3 Levels and Common Carotid Intima-Media Thickness in Overweight and Obese Patients

被引：11

作者：

De Pergola, Giovanni ^{[2
]}

Ciccone, Marco Matteo ^{[1
]}

Guida, Pietro ^{[1
]}

Morea, Gaetano ^{[1
]}

Giannuzzo, Emanuela ^{[2
]}

Cortese, Francesca ^{[1
]}

Scicchitano, Pietro ^{[1
]}

Favale, Stefano ^{[1
]}

Silvestris, Franco ^{[2
]}

机构：

[1] Univ Bari, Dept Emergency & Organ Transplantat, Sect Cardiovasc Dis, Sch Med, I-701242 Bari, Italy

[2] Univ Bari, Sch Med, Dept Internal Med & Clin Oncol, Clin Nutr Unit, I-701242 Bari, Italy

来源：

OBESITY FACTS | 2011年 / 4卷 / 02期

关键词：

C3; Obesity; Common carotid artery intima-media thickness; Cardiovascular risk; ACYLATION-STIMULATING PROTEIN; RISK-FACTORS; REACTIVE PROTEIN; ADIPOSE-TISSUE; INSULIN-RESISTANCE; SERUM C3; BODY-COMPOSITION; ARTERY; ASSOCIATION; DISEASE;

D O I：

10.1159/000327893

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: The study aim was to compare C3 levels with the common carotid artery intima-media thickness (CCA-IMT) in subjects of both genders, with a wide range of BMI, independently of age, gender, and abdominal obesity. Method: 140 euthyroid, mainly overweight/obese subjects (age 18-30 years) were examined. BMI, waist circumference, blood pressure, fasting insulin, glucose, lipids, C3 and C-reactive protein serum concentrations, and insulin resistance degree (estimated by homeostasis model assessment for insulin resistance (HOMA(IR))) were measured. Results: CCA-IMT was positively (p < 0.001) correlated with BMI, waist circumference, systolic and diastolic blood pressures, HOMA(IR), and insulin, CRP, and C3 serum levels. The multiple linear regression analysis showed that only male gender and waist circumference maintained an independent relation with the CCA-IMT. Conclusion: This study suggests that central fat accumulation and male gender independently increase the thickness of the arterial wall, whereas inflammation and inflammatory markers do not have an independent effect on this parameter.

引用

页码：159 / 163

页数：5

共 25 条

[1] Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity - Studies in subjects with various degrees of glucose tolerance and insulin sensitivity [J].