Melatonin prevents brain oxidative stress induced by obstructive jaundice in rats

被引：20

作者：

Cruz, Adolfo ^{[1
]}

Tunez, Isaac ^{[2
]}

Martinez, Ruben ^{[3
]}

Munoz-Castaneda, Juan Rafael ^{[3
]}

Ramirez, Luz Maria ^{[3
]}

Recio, Marta ^{[4
]}

Ochoa, Luis ^{[4
]}

Arjona, Alvaro ^{[1
]}

Montilla, Pedro ^{[2
]}

Muntane, Jordi ^{[3
]}

Padillo, Francisco J. ^{[1
]}

机构：

[1] Reina Sofia Univ Hosp, Dept Gen Surg, E-14004 Cordoba, Spain

[2] Univ Cordoba, Sch Med, Dept Biochem & Mol Biol, Cordoba, Spain

[3] Reina Sofia Univ Hosp, Res Unit, Cordoba, Spain

[4] Reina Sofia Univ Hosp, Dept Neurol, Cordoba, Spain

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2007年 / 85卷 / 16期

关键词：

brain; oxidative stress; melatonin; MDA; GSH; SOD; catalase; obstructive jaundice;

D O I：

10.1002/jnr.21436

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the study was to analyze the impact of melatonin on brain oxidative stress in experimental biliary obstruction. Cholestasis was done by a double ligature and section of the extrahepatic biliary duct. Melatonin was injected intraperitoneally (500 mu g/kg/day). Malon-dialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) contents were determined in the brain tissue. Biliary obstruction raised MDA and reduced GSH contents in the cortex, cerebellum, and hypothalamus areas. Moreover, the scavenger enzyme activity significantly dropped in all areas of the brain. Melatonin drastically reduced MDA concentration and enhanced GSH concentration, as well as all antioxidant enzyme activity in all brain areas obtained from the bile ductligated animals. In conclusion, the treatment with melatonin decreased lipid peroxidation and recovered the antioxidant status in the brain from cholestatic animals. (C) 2007 Wiley-Liss, Inc.

引用

页码：3652 / 3656

页数：5

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