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Mitochondrial genomes: anything goes

被引：433
作者：
Burger, G
Gray, MW
Lang, BF
机构：
[1] Univ Montreal, Dept Biochim, Programme Evolutionary Biol, Canadian Inst Adv Res, Montreal, PQ H3T 1J4, Canada
[2] Dalhousie Univ, Dept Biochem & Mol Biol, Programme Evolutionary Biol, Canadian Inst Adv Res, Halifax, NS B3H 1X5, Canada
来源：
TRENDS IN GENETICS | 2003年 / 19卷 / 12期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1016/j.tig.2003.10.012
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mitochondria have their own genetic system - a vestigial genome originating from an endosymbiotic alpha-proteobacterial ancestor. The genetic function of mitochondrial DNA (mtDNA) is well-conserved, being involved in a maximum of five mitochondrial processes: invariantly in respiration and/or oxidative phosphorylation and translation, and also in transcription, RNA maturation and protein import. Recent data from mitochondrial genomics research demonstrate that this genetic conservatism contrasts with an often-perplexing diversity in structure and gene expression mechanisms. In addition to outlining the extraordinary diversity of mtDNA, this review highlights the divergent trends in mitochondrial genome evolution in the various eukaryotic lineages, and examines the relationship between mitochondrial and nuclear genome evolution in a given organism.
引用
收藏
页码：709 / 716
页数：8
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