Phenolics with PPAR-γ ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-Ay mice

被引：77

作者：

Kuroda, M

Mimaki, Y ^{[1
]}

Sashida, Y

Mae, T

Kishida, H

Nishiyama, T

Tsukagawa, M

Konishi, E

Takahashi, K

Kawada, T

Nakagawa, K

Kitahara, M

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Lab Med Plant Sci, Tokyo 1920392, Japan

[2] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Nutr Chem Lab, Kyoto 6068502, Japan

[3] Tohoku Univ, Sch Med, Dept Internal Med, Div Mol Metab & Diabet, Sendai, Miyagi 9808575, Japan

[4] Kaneka Corp, Life Sci RD Ctr, Life Sci Res Labs, Takasago, Hyogo 6768688, Japan

[5] Kaneka Corp, Funct Foods Dev Div, Takasago, Hyogo 6768688, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 24期

关键词：

D O I：

10.1016/j.bmcl.2003.09.052

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The EtOAc extract of licorice (Glycyrrhiza uralensis roots) exhibited considerable PPAR-gamma ligand-binding activity. Bioassay-guided fractionation of the extract using a GAL-4-PPAR-gamma chimera assay method resulted in the isolation of two isoflavenes, one of which is a new compound named dehydroglyasperin D, an isoflavan, two 3-arylcoumarins, and an isoflavanone as the PPAR-gamma ligand-binding active ingredients of licorice. The isoprenyl group at C-6 and the C-2' hydroxyl group in the aromatic ring-C part in the isoflavan. isoflavene, or arylcoumarin skeleton were found to be the structural requirements for PPAR-gamma ligand-binding activity. Glycyrin, one of the main PPAR-gamma ligands of licorice, significantly decreased the blood glucose levels of genetically diabetic KK-A(y) mice. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4267 / 4272

页数：6

共 23 条

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