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Towards a facile synthesis of triarylethanones:: palladium-catalyzed arylation of ketone enolates under homogeneous and heterogeneous conditions

被引：46
作者：
Churruca, F [1 ]
SanMartin, R [1 ]
Carril, M [1 ]
Tellitu, I [1 ]
Domínguez, E [1 ]
机构：
[1] Euskal Herriko Unibertsitatea, Kimika Organikoa Saila II, Zientzi Fak, Bilbao, Spain
来源：
TETRAHEDRON | 2004年 / 60卷 / 10期
关键词：
arylation; ketones; palladium and compounds;
D O I：
10.1016/j.tet.2003.12.065
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The palladium-catalyzed regioselective alpha-monoarylation of deoxybenzoins and alpha,alpha-diarylation of acetophenones provides general, efficient access to 1,2,2-triarylethanones. After a comprehensive search for suitable experimental conditions to optimize such transformations, both reactions are alternatively conducted by means of either commercially available polymer-anchored catalysts or a very simple homogeneous catalytic system, thus avoiding the use of complex ligands. In addition, the synthesis of deoxybenzoins employing polymer-supported fibrous palladium catalysts is reported for the first time, and the excellent catalyst recycling properties suggest applicability to industrial purposes. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：2393 / 2408
页数：16
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