The role of autophagy in neonatal tissues - Just a response to amino acid starvation?

被引：60

作者：

Schiaffino, Stefano ^{[1
,2
,3
]}

Mammucari, Cristina ^{[1
,2
]}

Sandri, Marco ^{[1
,2
,4
]}

机构：

[1] Univ Padua, VIMM, I-35126 Padua, Italy

[2] Univ Padua, Dept Biomed Sci, I-35126 Padua, Italy

[3] CNR, Inst Neurosci, Padua, Italy

[4] Dulbecco Telethon Inst, Padua, Italy

来源：

AUTOPHAGY | 2008年 / 4卷 / 05期

关键词：

autophagy; neonatal tissues; amino acid starvation; glycogen degradation; cell remodeling; oxidative stress; FoxO;

D O I：

10.4161/auto.6143

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Autophagy is activated soon after birth in neonatal tissues and is essential for survival because mice deficient in Atg5 or Atg7 autophagy genes die within 1 day after birth. Amino acid starvation has been considered as a major deleterious effect of autophagy deficiency, since the concentration of amino acids in plasma was decreased by 20% in the two knockout models, whereas blood glucose and fatty acid levels were apparently not affected. However, autophagy may have other important functions in neonatal physiology, including glycogen degradation, programmed cell remodeling and response to oxidative stress.

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收藏

页码：727 / 730

页数：4

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