Molecular analysis of the heterogeneity of hereditary monosymptomatic sensorineural hearing loss

被引：1

作者：

Fiegert, P

LamprechtDinnesen, A

PreislerAdams, S

Deufel, T

机构：

来源：

LARYNGO-RHINO-OTOLOGIE | 1996年 / 75卷 / 03期

关键词：

hereditary hearing impairment; non-syndromic hearing loss; linkage analysis;

D O I：

10.1055/s-2007-997552

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: Genetic characterization of hereditary hearing impairment has progressed considerably with the mapping of nine chromosomal loci for monosymptomatic autosomal-inherited hearing loss over the last three years. Methods: Following thorough clinical evaluation, linkage analysis using microsatellite markers was performed in two large families from Westphalia/West Germany. Results: For all the dominant (DFNA1-4) and three autosomal-recessive loci (DFNB1-3) described to date, linkage was finally excluded. Conclusions: A high degree of genetic heterogeneity must be assumed. Identification of individual genes for monosymptomatic sensorineural hearing loss by linkage analysis in large pedigrees may help in molecular differentiation of hearing.

引用

页码：141 / 147

页数：15

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