A lexicon for homeodomain-DNA recognition

被引：26

作者：

Affolter, Markus ^{[1
]}

Slattery, Matthew ^{[2
]}

Mann, Richard S. ^{[2
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

[2] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

CELL | 2008年 / 133卷 / 07期

关键词：

D O I：

10.1016/j.cell.2008.06.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Decoding the cis-regulatory logic of eukaryotic genomes requires knowledge of the DNA-binding specificities of all transcription factors. New work (Berger et al., 2008; Noyes et al., 2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in many transcription factors. The data underscore the complexity of determining target specificities in vivo.

引用

收藏

页码：1133 / 1135

页数：3

相关论文

共 8 条

[1] Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential [J].

Berkes, CA ;

Bergstrom, DA ;

Penn, BH ;

Seaver, KJ ;

Knoepfler, PS ;

Tapscott, SJ .

MOLECULAR CELL, 2004, 14 (04) :465-477

[2]

Galant R, 2002, DEVELOPMENT, V129, P3115

[3] HOMEODOMAIN-DNA RECOGNITION [J].

GEHRING, WJ ;

QIAN, YQ ;

BILLETER, M ;

FURUKUBOTOKUNAGA, K ;

SCHIER, AF ;

RESENDEZPEREZ, D ;

AFFOLTER, M ;

OTTING, G ;

WUTHRICH, K .

CELL, 1994, 78 (02) :211-223

[4] Functional specificity of a Hox protein mediated by the recognition of minor groove structure [J].

Joshi, Rohit ;

Passner, Jonathan M. ;

Rohs, Remo ;

Jain, Rinku ;

Sosinsky, Alona ;

Crickmore, Michael A. ;

Jacob, Vinitha ;

Aggarwal, Aneel K. ;

Honig, Barry ;

Mann, Richard S. .

CELL, 2007, 131 (03) :530-543

[5] Transcription regulation and animal diversity [J].

Levine, M ;

Tjian, R .

NATURE, 2003, 424 (6945) :147-151

[6] Hox proteins meet more partners [J].

Mann, RS ;

Affolter, M .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1998, 8 (04) :423-429

[7] Hox cofactors in vertebrate development [J].

Moens, CB ;

Selleri, L .

DEVELOPMENTAL BIOLOGY, 2006, 291 (02) :193-206

[8] Defining the sequence-recognition profile of DNA-binding molecules [J].

Warren, CL ;

Kratochvil, NCS ;

Hauschild, KE ;

Foister, S ;

Brezinski, ML ;

Dervan, PB ;

Phillips, GN ;

Ansari, AZ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (04) :867-872