Anti-inflammatory drugs interacting with Zn(II), Cd(II) and Pt(II) metal ions

被引：161

作者：

Dendrinou-Samara, C

Tsotsou, G

Ekateriniadou, LV

Kortsaris, AH

Raptopoulou, CP

Terzis, A

Kyriakidis, DA

Kessissoglou, DP ^{[1
]}

机构：

[1] Aristotelian Univ Salonika, Dept Chem, Inorgan Chem Lab, GR-54006 Salonika, Greece

[2] Aristotelian Univ Salonika, Dept Chem, Biochem Lab, GR-54006 Salonika, Greece

[3] Theagen Canc Inst Thessaloniki, Salonika 54006, Greece

[4] NRCPS Demokritos, Inst Mat Sci, Aghia Paraskevi Attiki 15310, Greece

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1998年 / 71卷 / 3-4期

关键词：

anti-inflammatory; platinum; cadmium; zinc; structure; bioactivity;

D O I：

10.1016/S0162-0134(98)10051-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complexes of Zn(II), Cd(II) and Pt(II) metal ions with the anti-inflammatory drugs, 1-methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid (Tolmetin),alpha-methyl-4-(2-methylpropyl)benzeneacetic acid (Ibuprofen), 6-methoxy-alpha-methylnaphthalene-2-acetic acid (Naproxen) and 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (indomethacin) have been synthesized and characterized. In the structurally characterized Cd(naproxen)(2) complex the anti-inflammatory drug acts as bidentate chelate ligand coordinatively bound to metal ions through the deprotonated carboxylate group. Crystal data for 1: [C32H26O8Cd], orthorhombic, space group P22(1)2(1), a = 5.693(2) (Angstrom), b = 8.760(3) (Angstrom), c = 30.74(1) (Angstrom), V = 1533(1) Angstrom(3), Z = 2. Antibacterial and growth inhibitory activity is higher than that of the parent ligands oh the platinum(II) diamine compounds. (C) 1998 Elsevier Science Inc. All rights reserved.

引用

页码：171 / 179

页数：9

共 41 条

[1] REACTIONS OF PLATINUM(II) AQUA COMPLEXES .3. MULTINUCLEAR (N-15, PT-195, C-13, AND H-1) NMR-STUDY OF REACTIONS OF AQUA AND HYDROXO COMPLEXES WITH GLYCINE AND (METHYLIMINO)DIACETIC ACID [J].