Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population

被引：9

作者：

Bonneux, S. ^{[1
]}

Fransen, E. ^{[1
,4
]}

Van Eyken, E. ^{[1
]}

Van Laer, L. ^{[1
]}

Huyghe, J. ^{[1
]}

Van de Heyning, P. ^{[2
]}

Voets, A. ^{[3
]}

Gerards, M. ^{[3
]}

Stassen, A. P. M. ^{[3
]}

Hendrickx, A. T. M. ^{[3
]}

Smeets, H. J. M. ^{[3
]}

Van Camp, G. ^{[1
]}

机构：

[1] Univ Antwerp, Dept Med Genet, B-2020 Antwerp, Belgium

[2] Univ Antwerp Hosp, Dept Otorhinolaryngol, Antwerp, Belgium

[3] Maastricht Univ, Dept Genet & Cell Biol, Unit Clin Genom, Maastricht, Netherlands

[4] Univ Antwerp, StatUa Ctr Stat, B-2020 Antwerp, Belgium

来源：

MITOCHONDRION | 2011年 / 11卷 / 05期

关键词：

Mitochondrial DNA; Human Mitochondrial Resequencing Array; Age-related hearing impairment; Presbycusis; DNA COMMON DELETION; MUTATIONS; MTDNA; MICROARRAY; ASSOCIATION; PRESBYCUSIS; SEQUENCE; SUSCEPTIBILITY; HAPLOGROUPS; GENES;

D O I：

10.1016/j.mito.2011.05.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial DNA (mtDNA) mutations have been implicated in various age-related diseases. To further clarify the role of mtDNA variants in age-related hearing impairment (ARHI), we determined the DNA sequence of the entire mitochondrial genome of 400 individuals using the Affymetrix Human Mitochondrial Resequencing Array. These were the 200 worst hearing and the 200 best hearing from a collection of 947 Belgian samples. We performed association tests with individual mitochondrial variants, comparison of the mutation load, and association with European haplogroups and their interaction with environmental risk factors. We also tested the influence of rare variants on ARHI. None of these tests showed any association with ARHI. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：729 / 734

页数：6

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