Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis

被引:89
作者
Davis, Mark M. [1 ,2 ]
Altman, John D. [3 ,4 ]
Newell, Evan W. [1 ]
机构
[1] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA
[2] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA
[3] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA
[4] Emory Univ, Dept Microbiol & Immunol, Sch Med, Atlanta, GA 30322 USA
基金
美国国家卫生研究院;
关键词
CD8(+) T-CELLS; CLASS-II TETRAMERS; EX-VIVO ANALYSIS; IN-VIVO; ESCHERICHIA-COLI; IMMUNE-RESPONSE; VIRAL-INFECTION; HIGH-AFFINITY; B-CELLS; PRECURSOR FREQUENCIES;
D O I
10.1038/nri3020
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Labelling antigen-specific T cells with peptide-MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.
引用
收藏
页码:551 / 558
页数:8
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