Synthesis of 1-phosphonoalkylidene and -arylidene derivatives of nucleosides

被引：12

作者：

Endova, M ^{[1
]}

Masojidkova, M ^{[1
]}

Budesinsky, M ^{[1
]}

Rosenberg, I ^{[1
]}

机构：

[1] ACAD SCI CZECH REPUBL,INST ORGAN CHEM & BIOCHEM,CR-16610 PRAGUE 6,CZECH REPUBLIC

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 20期

关键词：

D O I：

10.1016/0040-4039(96)00562-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Redox reaction of chlorodiethylphosphite with nucleoside orthoesters results in efficient synthesis of 2',3'- or 3',5'O-((1-diethylphosphono)aralkyl)methyl derivatives of nucleosides as a novel type of isopolar phosphonate-based nucleotide analogues. The configuration of products was determined by 2D-ROESY NMR experiments. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3497 / 3500

页数：4

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