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DNA microarray gene expression analysis technology and its application to neurological disorders

被引：48
作者：
Greenberg, SA
机构：
[1] Brigham & Womens Hosp, Dept Neurol, Neuromuscular Div, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Childrens Hosp, Informat Program, Boston, MA USA
来源：
NEUROLOGY | 2001年 / 57卷 / 05期
关键词：
D O I：
10.1212/WNL.57.5.755
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
DNA microarray technology is currently an area of great interest. Also called "genechip" technology, it incorporates molecular genetics and computer science on a massive scale. This technology can rapidly provide a detailed view of the simultaneous expression of entire genomes and provide new insights into gene function, disease pathophysiology, disease classification, and drug development. In this review, the author discusses the basic theory behind genechip and other biologic chip technologies, their limitations given the current state of biologic knowledge and computational abilities, and their potential applications to the understanding of neurologic disorders.
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页码：755 / 761
页数：7
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