(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents

被引：98

作者：

Nomura, M ^{[1
]}

Kinoshita, S ^{[1
]}

Satoh, H ^{[1
]}

Maeda, T ^{[1
]}

Murakami, K ^{[1
]}

Tsunoda, M ^{[1
]}

Miyachi, H ^{[1
]}

Awano, K ^{[1
]}

机构：

[1] Kyorin Pharmaceut Co Ltd, Cent Res Labs, Nogi, Tochigi 3290114, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(99)00039-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure-activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl] -2-methoxy-N-[[4-trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：533 / 538

页数：6

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