Alcoholism and obesity: overlapping neuropeptide pathways?

被引:65
作者
Thiele, TE
Navarro, M
Sparta, DR
Fee, JR
Knapp, DJ
Cubero, I
机构
[1] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA
[4] Univ Almeria, Dept Neurociencia & Ciencias Salud, Almeria, Spain
关键词
ethanol consumption; melanocortin; agouti-related protein; neuropeptide Y; MTII;
D O I
10.1016/j.npep.2003.10.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ethanol is a caloric compound, and ethanol drinking and food intake are both appetitive and consummatory behaviors. Furthermore, both ethanol and food have rewarding properties. It is therefore possible that overlapping central pathways are involved with uncontrolled eating and excessive ethanol consumption. A growing list of peptides has been shown to regulate food intake and/ or energy homeostasis. Peptides such as the melanocortins, corticotropin releasing factor, and cholecystokinin promote reductions of food intake while others such as galanin and neuropeptide Y stimulate feeding. The present review highlights research aimed at determining if ingestive peptides also regulate voluntary ethanol intake, with an emphasis on the melanocortins and neuropeptide Y. It is suggested that research directed at ingestive peptides may expand our understanding of the neurobiological mechanisms that drive ethanol self-administration, and may reveal new therapeutic candidates for treating alcohol abuse and alcoholism. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:321 / 337
页数:17
相关论文
共 255 条
[1]   CURVE-SHIFT ANALYSIS OF SELF-STIMULATION IN FOOD-RESTRICTED RATS - RELATIONSHIP BETWEEN DAILY MEAL, PLASMA-CORTICOSTERONE AND REWARD SENSITIZATION [J].
ABRAHAMSEN, GC ;
BERMAN, Y ;
CARR, KD .
BRAIN RESEARCH, 1995, 695 (02) :186-194
[2]   Inverse agonism gains weight [J].
Adan, RAH ;
Kas, MJH .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2003, 24 (06) :315-321
[3]   Brain melanocortin receptors: From cloning to function [J].
Adan, RAH ;
Gispen, WH .
PEPTIDES, 1997, 18 (08) :1279-1287
[4]   HYPOTHALAMIC GALANIN-LIKE IMMUNOREACTIVITY AND ITS GENE-EXPRESSION IN RELATION TO CIRCULATING CORTICOSTERONE [J].
AKABAYASHI, A ;
WATANABE, Y ;
GABRIEL, SM ;
CHAE, HJ ;
LEIBOWITZ, SF .
MOLECULAR BRAIN RESEARCH, 1994, 25 (3-4) :305-312
[5]  
Alvaro JD, 1996, MOL PHARMACOL, V50, P583
[6]   Molecular and behavioral interactions between central melanocortins and cocaine [J].
Alvaro, JD ;
Taylor, JR ;
Duman, RS .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 304 (01) :391-399
[7]   CHRONIC ETHANOL INCREASES PROOPIOMELANOCORTIN GENE-EXPRESSION IN THE RAT HYPOTHALAMUS [J].
ANGELOGIANNI, P ;
GIANOULAKIS, C .
NEUROENDOCRINOLOGY, 1993, 57 (01) :106-114
[8]  
[Anonymous], 1993, BIOL NEUROPEPTIDE RE
[9]   PERIPHERAL INJECTIONS OF BOMBESIN AND CHOLECYSTOKININ AFFECT DIETARY SELF-SELECTION IN RATS [J].
AVERY, DD ;
LIVOSKY, M .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 25 (01) :7-11
[10]  
Bachtell RK, 2003, J NEUROSCI, V23, P2477