Troglitazone inhibits angiotensin II-induced DNA synthesis and migration in vascular smooth muscle cells

被引：68

作者：

Graf, K

Xi, XP

Hsueh, WA

Law, RE

机构：

[1] UNIV SO CALIF,SCH MED,DEPT MED,DIV ENDOCRINOL DIABET & HYPERTENS,LOS ANGELES,CA 90033

[2] HUMBOLDT UNIV BERLIN,VIRCHOW KLINIKUM,DEPT INTERNAL MED CARDIOL,BERLIN,GERMANY

[3] GERMAN HEART INST,BERLIN,GERMANY

来源：

FEBS LETTERS | 1997年 / 400卷 / 01期

关键词：

angiotensin II; DNA synthesis; MAP kinase; migration; smooth muscle cell; troglitazone;

D O I：

10.1016/S0014-5793(96)01371-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiotensin II (AII) plays a crucial role in controlling the proliferation and migration of vascular smooth muscle cells (VSMCs). The present study was undertaken to determine if troglitazone (Tro) has an effect on the G-protein coupled signaling through AII type I (AT-1) receptors in cultured rat aortic VSMCs. AII-induced MAP kinase activation was inhibited 67.9% by Tro. AII-induced DNA synthesis and migration was completely inhibited by Tro or by the AT-1 receptor blocker irbesartan, The present study demonstrates that troglitazone inhibits AII-induced DNA synthesis, migration and MAP kinase activation in VSMCs which are important molecular events for the development of neointimal hyperplasia and atherosclerosis.

引用

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页码：119 / 121

页数：3

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