Troglitazone inhibits angiotensin II-induced DNA synthesis and migration in vascular smooth muscle cells

被引:68
作者
Graf, K
Xi, XP
Hsueh, WA
Law, RE
机构
[1] UNIV SO CALIF,SCH MED,DEPT MED,DIV ENDOCRINOL DIABET & HYPERTENS,LOS ANGELES,CA 90033
[2] HUMBOLDT UNIV BERLIN,VIRCHOW KLINIKUM,DEPT INTERNAL MED CARDIOL,BERLIN,GERMANY
[3] GERMAN HEART INST,BERLIN,GERMANY
关键词
angiotensin II; DNA synthesis; MAP kinase; migration; smooth muscle cell; troglitazone;
D O I
10.1016/S0014-5793(96)01371-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Angiotensin II (AII) plays a crucial role in controlling the proliferation and migration of vascular smooth muscle cells (VSMCs). The present study was undertaken to determine if troglitazone (Tro) has an effect on the G-protein coupled signaling through AII type I (AT-1) receptors in cultured rat aortic VSMCs. AII-induced MAP kinase activation was inhibited 67.9% by Tro. AII-induced DNA synthesis and migration was completely inhibited by Tro or by the AT-1 receptor blocker irbesartan, The present study demonstrates that troglitazone inhibits AII-induced DNA synthesis, migration and MAP kinase activation in VSMCs which are important molecular events for the development of neointimal hyperplasia and atherosclerosis.
引用
收藏
页码:119 / 121
页数:3
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