The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice

被引：44

作者：

Sun, Hao ^{[1
]}

Cai, Hui ^{[1
]}

Fu, Yue ^{[2
]}

Wang, Qin ^{[1
]}

Ji, Kaihua ^{[1
]}

Du, Liqing ^{[1
]}

Xu, Chang ^{[1
]}

Tian, Lifang ^{[3
]}

He, Ningning ^{[1
]}

Wang, Jinhan ^{[1
]}

Zhang, Manman ^{[1
]}

Liu, Yang ^{[1
]}

Wang, Yan ^{[1
]}

Li, Jia ^{[4
]}

Liu, Qiang ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Tianjin Inst Radiol, Lab Radiat Med & Radiat Injury Effects, 238 Baidi Rd, Tianjin, Peoples R China

[2] Natl Accreditat Serv Conform Assessment, Beijing, Peoples R China

[3] Peoples Hosp Renqiu City, Renqiu, Hebei, Peoples R China

[4] Capital Med Univ, Elect Power Teaching Hosp, Beijing, Peoples R China

来源：

DOSE-RESPONSE | 2020年 / 18卷 / 02期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

radiation; biomarker; resveratrol; SIRT1; NLRP3; NF-KAPPA-B; TOTAL-BODY IRRADIATION; ACTIVATING SIRT1; TNF-ALPHA; EXPRESSION; HEALTH; CD40;

D O I：

10.1177/1559325820931292

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

With the extensive application of radiotherapy in various cancers, its side effects in tissues adjacent to cancers are garnering much attention. Intestines are sensitive to irradiation due to its rapid proliferation, and irradiation-induced enteric inflammation is common in patients with pelvic peritoneal tumors. Sirt1, class III protein deacetylase, could lead to transcriptional repression of various inflammation-associated genes, and our previous study has proved its relationship with interleukin (IL)-1 beta. Here we show that resveratrol, the activator of Sirt1, could alleviate the bowel inflammation induced by irradiation and the expression of Sirt1 is consistent with the inflammation level. We further identified in vivo that Sirt1 repress the expression of IL-1 beta by the repression of NLR Family, Pyrin Domain Containing protein 3 (NLRP3) expression. In conclusion, this study confirms resveratrol acts against radiation-induced inflammatory bowel disease via NLRP-3 inflammasome repression in mice and supports Sirt1 as a potential biomarker and therapy target in intestinal radiation protection.

引用

页数：10

共 35 条

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