Pilot study to determine the impact of a multidisciplinary educational intervention in patients hospitalized with heart failure

Background Patients with heart failure (HF) face challenges complying with multidrug regimens. Objectives To examine the impact of a compliance enhancing intervention on medication compliance and morbidity in HF. Design Patients were randomized to either usual care or an inhospital educational intervention delivered by a multidisciplinary team (intervention). Setting Acute medical and surgical units at a teaching hospital. Patients One hundred thirty four patients with a clinical diagnosis of HF and a left ventricular election fraction of <40% requiring long-term medical treatment. Main Outcome Measures A validated HF-specific instrument provided a measure of knowledge. We characterized patients as noncompliant if pharmacy refill data suggested they had taken <= 0.80 of their medication. We measured quality of life using the Minnesota Living with Heart Failure Questionnaire and the Short Form 36 and conducted a time to first event analysis of a composite end point including mortality, readmissions, and emergency department visits. Results The Intervention group showed higher knowledge scores at discharge and 1 year (P = .05). The risk of noncompliance in Intervention patients varied from 0.78 (95% CI 0.33-1.89) for ACE-I (13% Intervention, 17% Control) to 1.02 (0.49-2.12) for diuretics (23% Intervention, 23% Control). Quality of life improved in both groups over time; the only difference between groups favored the Intervention (Minnesota Living with Heart Failure Questionnaire, P = .04). The composite end point occurred in 67% of control and 60% of Intervention patients (hazard ratio 0.85, 95% CI 0.55-1.30). Conclusions An inhospital educational intervention improved knowledge and, possibly, quality of life and maybe useful as part of a comprehensive compliance enhancing strategy inpatients with HF.