Relationship of serum osteoprotegerin with arterial stiffness, preclinical atherosclerosis, and disease activity in patients with ankylosing spondylitis

被引:20
作者
Beyazal, Munevver Serdaroglu [1 ,2 ]
Erdogan, Turan [3 ]
Turkyilmaz, Aysegul Kucukali [1 ]
Devrimsel, Gul [1 ]
Cure, Medine Cumhur [4 ]
Beyazal, Mehmet [5 ]
Sahin, Ismail [3 ]
机构
[1] Recep Tayyip Erdogan Univ, Sch Med, Dept Phys Med & Rehabil, Rize, Turkey
[2] Recep Tayyip Erdogan Univ, Tip Fak, Fiziksel Tip & Rehabil Klin, TR-53100 Rize, Turkey
[3] Recep Tayyip Erdogan Univ, Sch Med, Dept Cardiol, Rize, Turkey
[4] Recep Tayyip Erdogan Univ, Sch Med, Dept Biochem, Rize, Turkey
[5] Recep Tayyip Erdogan Univ, Sch Med, Dept Radiol, Rize, Turkey
关键词
Ankylosing spondylitis; Cardiovascular risk; Carotid intima media thickness; Osteoprotegerin; Pulse wave velocity; INTIMA-MEDIA THICKNESS; RISK-FACTOR; ENDOTHELIAL ACTIVATION; CARDIOVASCULAR-DISEASE; ARTHRITIS; BONE; DYSFUNCTION; CYTOKINES; SEVERITY; MARKER;
D O I
10.1007/s10067-016-3198-9
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Patients with ankylosing spondylitis (AS) reportedly have a higher mortality and morbidity risk. Osteoprotegerin (OPG) was recently defined as an important cardiovascular (CV) marker in the general population. We aimed to assess the relationship of serum OPG levels with arterial stiffness, carotid intima media thickness (CIMT), and clinical and laboratory data in AS patients. We examined 60 AS patients without CV disease or risk factors and 50 healthy controls. Disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Ankylosing Spondylitis Disease Activity Score (ASDAS), whereas functional capacity was evaluated using the Bath Ankylosing Spondylitis Functional Index (BASFI). Serum OPG levels were measured with the enzyme-linked immunosorbent assay. Carotid-femoral pulse wave velocity (PWV) was used as an indicator of arterial stiffness, whereas CIMT (examined via carotid ultrasonography) was used to evaluate preclinical atherosclerosis. The mean serum OPG level, PWV, and CIMT were significantly higher in AS patients than in controls (106.7 +/- 50.9 vs. 58.1 +/- 12.7 pg/mL; 7.4 +/- 1.8 vs. 6.2 +/- 1.2 m/s; 0.72 +/- 0.13 vs. 0.57 +/- 0.07 mm, respectively; P < 0.001 for all). In AS patients, the serum OPG levels were not significantly correlated with PWV and CIMT but were significantly correlated with erthrocyte sedimentation rate, BASFI, and ASDAS. AS patients without CV disease or risk exhibited high OPG levels and increased PWV and CIMT values. Although OPG levels were not significantly correlated with PWV or CIMT, future long-term follow-up studies will help define the predictive value of OPG in these patients.
引用
收藏
页码:2235 / 2241
页数:7
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