AC133 expression on acute myeloid leukemia blasts: correlation to FAB and to CD34 expression and possible implications for peripheral blood progenitor cell purging in AML

被引:10
作者
Fauth, F [1 ]
Weidmann, E [1 ]
Martin, H [1 ]
Schneider, B [1 ]
Sonnhoff, S [1 ]
Hoelzer, D [1 ]
机构
[1] Klinikum Johann Wolfgang Goethe Univ, Dept Hematol, Med Klin 3, D-60590 Frankfurt, Germany
关键词
AC133; surface antigens; acute myeloblastic leukemia; autologous peripheral blood progenitor cell transplantation;
D O I
10.1016/S0145-2126(00)00112-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
AC133 is an antigen expressed on CD34 + hematopoietic progenitor cells. In acute myeloid leukemia (AML) it is expressed on leukemic blasts of most FAB subtypes. However, few data are available regarding coexpression of other surface antigens. We measured AC133 expression on AML blasts from 28 consecutive patients at initial diagnosis (n = 26) or at diagnosis of first relapse (n = 2) and on 26 leukapheresis products from 14 patients. In AML AC133 correlated with CD34 expression (Spearman r = 0.4711, P = 0.0114) and even stronger with combined CD34/CD33 expression (Spearman r = 0.5083, P = 0.0068). In leukapheresis products AC133 expression correlated with CD34 expression (Spearman r = 0.7495, P = 0.002) and the yield of the obtained amount of CD34 + cells (Spearman r = 0.6484, P = 0.0121). In conclusion AC133 expression is closely related to CD34 expression in AML. In leukapheresis products AC133 provides an additional marker for selection of PBPC autografts in AC133-AML. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:191 / 196
页数:6
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