RNA interference: on the road to an alternate therapeutic strategy!

被引：63

作者：

Dave, RS ^{[1
]}

Pomerantz, RJ ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Ctr Human Virol & Biodef, Div Infect Dis & Environm Med, Philadelphia, PA 19107 USA

来源：

REVIEWS IN MEDICAL VIROLOGY | 2003年 / 13卷 / 06期

关键词：

D O I：

10.1002/rmv.407

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RNA interference (RNAi) is a newly described natural biological phenomenon mediated by small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular enzymes. RNAi has become a method of choice for studying gene function, especially in mammalian systems. With proof-of-concept studies already presented against a wide variety of human pathogens and several innovative methods of delivering the siRNA to a wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy is becoming increasingly clear. This review presents recent advances in this direction. Copyright (C) 2003 John Wiley Sons, Ltd.

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页码：373 / 385

页数：13

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